HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.

doi:10.1159/000015234

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Article

HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.

Cytogenetics and cell genetics - 1 Jan 1999

Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I

Abstract excerpt

HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1-->p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny...

Topics

Animals
Base Sequence
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 2
DNA Primers
Genes, Homeobox
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Intestines
Mice
Mice, Knockout
Phenotype
Species Specificity

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Open in PubMed

Identifiers

PMID: 10343123
DOI: 10.1159/000015234

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