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Article

Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.

Cancer detection and prevention - 1 Jan 1999

Taioli E, Bradlow H L, Garbers S V, Sepkovic D W, Osborne M P, Trachman J, Ganguly S, Garte S J

Abstract excerpt

The endogenous metabolism of estrogens is primarily oxidative and involves hydroxylation of the steroid at either C2 (2-OHE1) or C16 (16-OHE1). While the 2-OHE1 metabolites are essentially devoid of peripheral biological activity, 16-OHE1 is an estrogen agonist. There is evidence of an associatio...

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Source

Identifiers

PMID: 10337002
DOI: 10.1046/j.1525-1500.1999.09912.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10337002-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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