Article
TGF-beta1 favors the development of fast type identity during soleus muscle regeneration.
Journal of muscle research and cell motility - 1 Jan 2006
Noirez Philippe, Torres Sandra, Cebrian José, Agbulut Onnik, Peltzer Juliette, Butler-Browne Gillian, Daegelen Dominique, Martelly Isabelle, Keller Angelica, Ferry Arnaud
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is known to be expressed in the environment of developing fast muscle fibres during ontogenesis. In the present study, we have examined effects of administration of either TGF-beta1 or neutralizing TGF-beta1 antibody on the induction of fast type phenotype in regenerating skeletal muscles in rats. Expressions of fast and slow myosin heavy chain (MHC) isoforms were...
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