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Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity.

Biochimica et biophysica acta - 14 May 1999

Nguyen D C, Crowe D L

Abstract excerpt

The ends of human chromosomes (telomeres) consist of tandem repeats of the sequence TTAGGG. Telomeres lose up to 200 base pairs of DNA per cell division due to the inability of DNA polymerase to completely replicate the chromosomal ends. Chromosomal shortening ultimately leads to senescence and cell death in normal cells. However, some immortal cells do not lose telomeric sequence during DNA replication. Many...

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PMID: 10320773
DOI: 10.1016/s0167-4781(99)00044-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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