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Article

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

Cell - 30 Apr 1999

Spiess C, Beil A, Ehrmann M

Abstract excerpt

Misfolding or unfolding of polypeptides can occur as a consequence of environmental stress and spontaneous mutation. The abundance of general chaperones and proteases suggests that cells distinguish between proteins that can be refolded and "hopeless" cases fated to enter the proteolytic pathway. The mechanisms controlling this key metabolic decision are not well understood. We show here that the widely conserved...

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PMID: 10319814
DOI: 10.1016/s0092-8674(00)80743-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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