Article
PDZ domains determine the native oligomeric structure of the DegP (HtrA) protease.
Molecular microbiology - 1 Aug 1999
Sassoon N, Arié J P, Betton J M
Abstract excerpt
DegP (HtrA) is a periplasmic heat shock serine protease of Escherichia coli that degrades misfolded proteins at high temperatures. Biochemical and biophysical experiments have indicated that the purified DegP exists as a hexamer. To examine whether the PDZ domains of DegP were required for oligomerization, we constructed a DegP variant lacking both PDZ domains. This truncated variant, DegPDelta, exhibited no...
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