Article
Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter.
Alcoholism, clinical and experimental research - 1 Apr 1999
Okubo T, Harada S, Higuchi S, Matsushita S
Abstract excerpt
In the central nervous system, cholecystokinin (CCK) is an important neurotransmitter that gives the influences on firings, anxiety, notiception, and dopamine-related behavior. CCK co-exists in the dopaminergic neurons, interacting with dopamine. In this study, we examined the genetic variant -45 C to T substitution of the CCK gene promoter region among 195 healthy Japanese and 174 patients with alcohol...
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