Article
Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 2007
Naushad Sm, Jamal Nurul Jain, Angalena R, Prasad C Krishna, Devi A Radha Rama
Abstract excerpt
To investigate the role of methylene tetrahydrofolate reductase (MTHFR) (677 C-->T and 1298 A-->C), factor V (1691 G-->A), factor II (20210 G-->A) genetic polymorphisms and hyperhomocysteinemia in the aetiology of deep vein thrombosis (DVT) in 163 cases and 163 controls. Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping, reverse-phase high-performance liquid chromatography...
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