Article
Structure of a Cys25-->Ser mutant of human cathepsin S.
Acta crystallographica. Section D, Biological crystallography - 1 Mar 2002
Turkenburg Johan P, Lamers Marieke B A C, Brzozowski A Marek, Wright Lisa M, Hubbard Roderick E, Sturt Simone L, Williams David H
Abstract excerpt
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis...
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