Article
Association of (Q)R/KRAA positive HLA-DRB1 alleles with disease progression in early active and severe rheumatoid arthritis.
The Journal of rheumatology - 1 Apr 1999
Seidl C, Koch U, Buhleier T, Möller B, Wigand R, Markert E, Koller-Wagner G, Seifried E, Kaltwasser J P
Abstract excerpt
OBJECTIVE: We have shown that HLA-DRB1 alleles influence inflammatory activity in patients with early active and severe rheumatoid arthritis (RA). Therefore, we analyzed the effect of HLA-DRB1 alleles on disease progression in patients with early RA during a clinical followup period of 18 months. METHODS: Disease progression was defined by the Larsen Score, the Ritchie Index (RI), and the Health Assessment...
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