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Article

Phenotypic switching in Candida albicans is controlled by a SIR2 gene.

The EMBO journal - 4 May 1999

Pérez-Martín J, Uría J A, Johnson A D

Abstract excerpt

We report the cloning of a gene from the human fungal pathogen Candida albicans with sequence and functional similarity to the Saccharomyces cerevisiae SIR2 gene. Deletion of the gene in C. albicans produces a dramatic phenotype: variant colony morphologies arise at frequencies as high as 1 in 10. The morphologies resemble those described previously as part of a phenotypic switching system proposed to contribute...

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Identifiers

PMID: 10228170
DOI: 10.1093/emboj/18.9.2580
PMCID: PMC1171338

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