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Article

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.

Antimicrobial agents and chemotherapy - 1 Jul 2004

Mellado E, Garcia-Effron G, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela J L

Abstract excerpt

Five clinical isolates of Aspergillus fumigatus that exhibited similar patterns of reduced susceptibility to itraconazole and other triazole drugs were analyzed. Sequence analysis of genes (cyp51A and cyp51B) encoding the 14alpha-sterol demethylases revealed that all five strains harbored mutations in cyp51A resulting in the replacement of methionine at residue 220 by valine, lysine, or threonine. When the...

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Antifungal Agents
Aspergillus fumigatus
Azoles
Cytochrome P-450 Enzyme System
Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fungal Proteins

Microbial Sensitivity Tests

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Identifiers

PMID: 15215142
DOI: 10.1128/AAC.48.7.2747-2750.2004
PMCID: PMC434164

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