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Article

Hypermutation in derepressed operons of Escherichia coli K12.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999

Wright B E, Longacre A, Reimers J M

Abstract excerpt

This article presents evidence that starvation for leucine in an Escherichia coli auxotroph triggers metabolic activities that specifically target the leu operon for derepression, increased rates of transcription, and mutation. Derepression of the leu operon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress (the stringent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10220423
DOI: 10.1073/pnas.96.9.5089
PMCID: PMC21821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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