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Article

The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region.

The Journal of pathology - 1 Nov 1998

Sturm P D, Hruban R H, Ramsoekh T B, Noorduyn L A, Tytgat G N, Gouma D J, Offerhaus G J

Abstract excerpt

It can be difficult to distinguish between malignant and benign disease of the region of the head of the pancreas using conventional methods. K-ras and p53 alterations occur frequently in malignancies in this region and are therefore candidate tumour markers. To define the utility of these alterations in interpreting pancreatic head cytology, the present study investigated to what extent alterations in the...

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PMID: 10211112
DOI: 10.1002/(SICI)1096-9896(1998110)186:3<247::AID-PATH179>3.0.CO;2-J

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