Article
Production of avirulent Mycobacterium bovis strains by illegitimate recombination with deoxyribonucleic acid fragments containing an interrupted ahpC gene.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 1997
Wilson T, Wards B J, White S J, Skou B, de Lisle G W, Collins D M
Abstract excerpt
SETTING: Molecular genetic techniques have been used to elucidate virulence determinants and to produce vaccines for many bacterial pathogens but reliable techniques for slow-growing mycobacteria have not been available. OBJECTIVE: Oxidative defence genes including ahpC are involved in isoniazid resistance of strains of the Mycobacterium tuberculosis complex. The aim of this study was to inactivate ahpC by...
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