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Article

Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53.

Molecular carcinogenesis - 1 Mar 1999

Tyner S D, Choi J, Laucirica R, Ford R J, Donehower L A

Abstract excerpt

A number of transgenic animal model systems have addressed the mechanistic role of p53 loss in tumor progression. However, many of these tumor models have analyzed p53 function in the context of other transgenes expressing activated oncogenes or defective tumor suppressor genes generated by gene targeting. To examine the role of p53 loss independent of other exogenous oncogenic influences, we analyzed some of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10204804
DOI: 10.1002/(sici)1098-2744(199903)24:3<197::aid-mc6>3.0.co;2-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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