Article
Sequence polymorphisms in the apolipoprotein(a) gene and their association with lipoprotein(a) levels and myocardial infarction. The ECTIM Study.
Atherosclerosis - 1 Jun 1999
Brazier L, Tiret L, Luc G, Arveiler D, Ruidavets J B, Evans A, Chapman J, Cambien F, Thillet J
Abstract excerpt
Lp(a) concentrations are largely determined by apo(a) isoform size, but several studies have shown that apo(a) isoforms could not entirely explain the increase of Lp(a) levels observed in patients with coronary heart disease (CHD). Since up to 90% of the variance in Lp(a) levels has been suggested to be attributable to the apo(a) locus, the hypothesis that polymorphisms of the apo(a) gene other than size could...
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