Progress toward the cloning of CLN6, the gene underlying a variant LINCL.

Abstract excerpt

Marked clinical heterogeneity is seen in the late-infantile subtype of NCL (LINCL), complicating genetic analysis. In addition to the classical subtype, encoded by CLN2 on chromosome 11p15.5, several variant subtypes have also been described. In this paper, we report our progress in cloning a variant LINCL gene mapped in a small group of Costa Rican families. Clinically, these patients appear similar to classical...

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• Share to Chromosomes, Artificial, Yeast
• Share to Chromosomes, Human, Pair 15
• Share to Cloning, Molecular