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Article

The promoter and the enhancer region of the KLK 3 (prostate specific antigen) gene is frequently mutated in breast tumours and in breast carcinoma cell lines.

British journal of cancer - 1 Mar 1999

Majumdar S, Diamandis E P

Abstract excerpt

KLK3 or prostate specific antigen (PSA) is a serine protease, which is an established tumour marker of prostatic adenocarcinoma. PSA is now used widely for the diagnosis and monitoring of patients with prostate cancer. Recent studies have demonstrated that about 70% of breast cancers produce PSA. In this study, we examined the molecular mechanism underlying the expression of the PSA gene in breast cancer and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Androgen

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Source

Open in PubMed Open full text

Identifiers

PMID: 10188912
DOI: 10.1038/sj.bjc.6690254
PMCID: PMC2362704

Genes

KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The promoter and the enhancer region of the KLK 3 (prostate specific antigen) gene is frequently mutated in breast tumours and in breast carcinoma cell lines.PMID 10188912Read ↗

Frequent detection of mutations in the 5' flanking region of the prostate-specific antigen gene in female breast cancer.Semantic proximity Read ↗

A 6-kb Promoter Fragment Mimics in Transgenic Mice the Prostate-Specific and Androgen-Regulated Expression of the Endogenous Prostate-Specific Antigen Gene in HumansSemantic proximity Read ↗

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility.Semantic proximity Read ↗

Prostate-specific Antigen Expression Is Regulated by an Upstream EnhancerSemantic proximity Read ↗

Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.Semantic proximity Read ↗

An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter.Semantic proximity Read ↗

Very low PSA concentrations and deletions of the KLK3 gene.Semantic proximity Read ↗

Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels.Semantic proximity Read ↗

Novel polymorphisms in prostate specific antigen gene and its association with prostate cancer.Semantic proximity Read ↗

Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms.Semantic proximity Read ↗

ARE-I polymorphism on PSA gene in prostate cancer patients of a Turkish population.Semantic proximity Read ↗

Unusual Alternative Splicing within the Human Kallikrein Genes KLK2 and KLK3 Gives Rise to Novel Prostate-specific ProteinsSemantic proximity Read ↗

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