Article
Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels.
Journal of the National Cancer Institute - 16 Jul 2003
Cramer Scott D, Chang Bao-Li, Rao Anuradha, Hawkins Gregory A, Zheng S Lilly, Wade Wendy N, Cooke Roger T, Thomas Leanne N, Bleecker Eugene R, Catalona William J, Sterling David A, Meyers Deborah A, Ohar Jill, Xu Jianfeng
Abstract excerpt
BACKGROUND: Recent evidence suggests that genetic variation in the promoter of the prostate-specific antigen (PSA) gene may contribute to individual variation in serum PSA levels. However, polymorphisms associated with variations in PSA levels have not been identified. METHODS: We used the polymerase chain reaction to amplify the promoter region of the PSA genes (nucleotide positions -3873 to -5749 with respect...
Topics
- Aged
- Allelic Imbalance
- Analysis of Variance
- Biomarkers, Tumor
- Cloning, Molecular
- Gene Amplification
- Genetic Markers
- Genotype
- Haplotypes
- Humans