Article
Novel polymorphisms in prostate specific antigen gene and its association with prostate cancer.
Anticancer research - 1 Jan 2000
Yang Q, Shan L, Segawa N, Nakamura M, Nakamura Y, Mori I, Sakurai T, Kakudo K
Abstract excerpt
Prostate-specific antigen (PSA) is now used widely for the diagnosis and monitoring of patients with prostate cancer. The PSA gene is a target of the androgen receptor (AR) which interacts with androgen response elements (AREs) in the PSA gene promoter. Recently, we identified two novel polymorphisms in the PSA promoter ARE2 region in breast cancer. We hypothesized that some genetic variations might also exist in...
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