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<i>Leishmania donovani</i> Infection of a Susceptible Host Results in CD4<sup>+</sup> T‐Cell Apoptosis and Decreased Th1 Cytokine Production

1 Mar 1999

Abstract excerpt

The disease visceral leishmaniasis is caused by a protozoan parasite, Leishmania donovani and is characterized by depressed cell-mediated immunity (CMI) and unhindered parasite growth in a susceptible host. The opposite trend is observed in a resistant host. However, the mechanism of this loss of CMI during the progressive disease is unknown as yet. In this report, we demonstrate that more than 40% of CD4+ T...

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PMID: 10102649
DOI: 10.1046/j.1365-3083.1999.00486.x

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