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Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival

24 Oct 2016

Abstract excerpt

Members of the Bcl-2 family are major regulators of apoptosis in mammalian cells and hence infection-induced perturbations in their expression could result into elimination of the parasites or creation of a niche favoring survival. In this investigation, we uncover a novel role of host Bcl-2 in sustaining Leishmania donovani infection. A rapid two-fold increase in Bcl-2 expression occurred in response to parasite...

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PMID: 27826299
DOI: 10.3389/fimmu.2016.00456

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