Comparison of the Effects of<i>Leishmania major</i>or<i>Leishmania donovani</i>Infection on Macrophage Gene Expression

Abstract excerpt

The intracellular parasite Leishmania causes a wide spectrum of human disease, ranging from self-resolving cutaneous lesions to fatal visceral disease, depending on the species of Leishmania involved. The mechanisms by which different Leishmania species cause different pathologies are largely unknown. We have addressed this question by comparing the gene expression profiles of bone marrow-derived macrophages...

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