Article
<i>Leishmania</i> disease development depends on the presence of apoptotic promastigotes in the virulent inoculum
31 Aug 2006
Abstract excerpt
The obligate intracellular pathogen Leishmania major survives and multiplies in professional phagocytes. The evasion strategy to circumvent killing by host phagocytes and establish a productive infection is poorly understood. Here we report that the virulent inoculum of Leishmania promastigotes contains a high ratio of annexin A5-binding apoptotic parasites. This subpopulation of parasites is characterized by a...
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