Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid detection of MYCN gene amplification and telomerase expression in neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 1999

Hiyama E, Hiyama K, Yokoyama T, Fukuba I, Yamaoka H, Shay J W, Matsuura Y

Abstract excerpt

Amplification of the MYCN gene and high telomerase activity predict a poor prognosis for the patients with neuroblastoma. We used PCR techniques for rapid detection of MYCN gene amplification and human telomerase reverse transcriptase (hTERT) expression in neuroblastoma specimens. The detection of MYCN gene amplification is based on differential PCR in which three primer pairs were used to coamplify a 178-bp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to Neoplasm Proteins

Share to Neuroblastoma

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Telomerase

Source

Identifiers

PMID: 10100712

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid detection of MYCN gene amplification and telomerase expression in neuroblastoma.PMID 10100712Read ↗

Rapid and accurate determination of MYCN copy number and 1p deletion in neuroblastoma by quantitative PCR.Semantic proximity Read ↗

A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastomaSemantic proximity Read ↗

MYCN RNA levels determined by quantitative in situ hybridization is better than MYCN gene dosages in predicting the prognosis of neuroblastoma patients.Semantic proximity Read ↗

Prediction of <i>MYCN</i> Amplification in Neuroblastoma Using Serum DNA and Real-Time Quantitative Polymerase Chain ReactionSemantic proximity Read ↗

A prospective evaluation of liquid biopsy for detecting MYCN amplification in neuroblastoma patientsSemantic proximity Read ↗

The performance of semi-quantitative differential PCR is similar to that of real-time PCR for the detection of the MYCN gene in neuroblastomasSemantic proximity Read ↗

Telomerase Is a Prognostic Marker of Poor Outcome and a Therapeutic Target in NeuroblastomaSemantic proximity Read ↗

Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplificationSemantic proximity Read ↗

Detection of <i>MYCN</i> Amplification in Serum DNA Using Conventional Polymerase Chain ReactionSemantic proximity Read ↗

MYCN protein stability is a better prognostic indicator in neuroblastomaSemantic proximity Read ↗

Heterogeneity of <i>MYCN</i> amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasisSemantic proximity Read ↗

Immunohistochemical Detection of Telomerase (hTERT) Protein in Human Cancer Tissues and a Subset of Cells in Normal TissuesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.