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Article

A prospective evaluation of liquid biopsy for detecting MYCN amplification in neuroblastoma patients

1 May 2019

Abstract excerpt

BACKGROUND: Our previous study reported a method for determining MYCN gene amplification (MNA) status using cell-free DNA in serum. We prospectively analyzed the serum MNA status using sera obtained before the initial diagnosis from patients with neuroblastoma and evaluated the utility of this method. METHODS: Eighty patients were enrolled in the study. The serum MYCN/NAGK ratio was assessed for all cases....

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PMID: 31053863
DOI: 10.1093/jjco/hyz063

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