Article
C-terminal cysteines of Tn501 mercuric ion reductase.
Biochemistry - 18 Feb 1992
Moore M J, Miller S M, Walsh C T
Abstract excerpt
Mercuric ion reductase (MerA) catalyzes the reduction of Hg(II) to Hg(0) as the last step in the bacterial mercury detoxification pathway. A member of the flavin disulfide oxidoreductase family, MerA contains an FAD prosthetic group and redox-active disulfide in its active site. However, the presence of these two moieties is not sufficient for catalytic Hg(II) reduction, as other enzyme family members are...
Topics
- Alanine
- Base Sequence
- Binding Sites
- Catalysis
- Cysteine
- Escherichia coli
- Kinetics
- Mercuric Chloride
- Mercury
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Niacinamide