Article
Protein conformational changes in the bacteriorhodopsin photocycle.
Journal of molecular biology - 19 Mar 1999
Subramaniam S, Lindahl M, Bullough P, Faruqi A R, Tittor J, Oesterhelt D, Brown L, Lanyi J, Henderson R
Abstract excerpt
We report a comprehensive electron crystallographic analysis of conformational changes in the photocycle of wild-type bacteriorhodopsin and in a variety of mutant proteins with kinetic defects in the photocycle. Specific intermediates that accumulate in the late stages of the photocycle of wild-type bacteriorhodopsin, the single mutants D38R, D96N, D96G, T46V, L93A and F219L, and the triple mutant...
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