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Article

Bacteriorhodopsin folds through a poorly organized transition state.

Journal of the American Chemical Society - 26 Nov 2014

Schlebach Jonathan P, Woodall Nicholas B, Bowie James U, Park Chiwook

Abstract excerpt

The folding mechanisms of helical membrane proteins remain largely uncharted. Here we characterize the kinetics of bacteriorhodopsin folding and employ φ-value analysis to explore the folding transition state. First, we developed and confirmed a kinetic model that allowed us to assess the rate of folding from SDS-denatured bacteriorhodopsin (bRU) and provides accurate thermodynamic information even under...

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Identifiers

PMID: 25369295
DOI: 10.1021/ja508359n
PMCID: PMC4277764

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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