Article
Irregular expression of hyaluronan and its CD44 receptor is associated with metastatic phenotype in laryngeal squamous cell carcinoma.
Virchows Archiv : an international journal of pathology - 1 Jan 1999
Hirvikoski P, Tammi R, Kumpulainen E, Virtaniemi J, Parkkinen J J, Tammi M, Johansson R, Agren U, Karhunen J, Kosma V M
Abstract excerpt
The distributions of hyaluronan (HA) and its CD44 receptor were studied in 24 normal, 27 dysplastic samples of laryngeal epithelium and in 172 squamous cell carcinomas (LSCC), using a specific probe prepared from cartilage proteoglycan (bHABC, biotinylated hyaluronan binding complex) and a monoclonal antibody (Hermes 3). HA and CD44 were expressed similarly in all normal and about 90% of dysplastic and neoplastic...
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