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Article

In vitro surfactant protein B deficiency inhibits lamellar body formation.

American journal of respiratory cell and molecular biology - 1 Aug 2003

Foster Cherie D, Zhang Peggy X, Gonzales Linda W, Guttentag Susan H

Abstract excerpt

Surfactant protein (SP) B is essential for normal pulmonary surfactant activity and lamellar body genesis in type 2 cells. However, the role of SP-B in lamellar body genesis is poorly understood. We developed an adenovirus vector expressing antisense SP-B as an alternative in vitro model of SP-B deficiency to begin to explore the role of SP-B in lamellar body genesis. RT-PCR analysis revealed that antisense SP-B...

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Identifiers

PMID: 12649122
DOI: 10.1165/rcmb.2002-0149OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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