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Article

Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population.

The Journal of infectious diseases - 1 Apr 1999

van Loo I H, van der Heide H G, Nagelkerke N J, Verhoef J, Mooi F R

Abstract excerpt

The population structure of Bordetella pertussis in The Netherlands in 5 successive periods, encompassing 1949-1996, was analyzed by DNA typing ("fingerprinting"). In 10 years following the introduction of wide-scale vaccination in 1953, a decrease in genotypic diversity (GD) was observed, suggesting clonal expansion of strains that were adapted to vaccine-induced immunity. In subsequent periods, GD increased to...

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PMID: 10068587
DOI: 10.1086/314690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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