Resistance to human cytomegalovirus infection may be influenced by genetic polymorphisms of the tumour necrosis factor-alpha and interleukin-1 receptor antagonist genes.

Abstract excerpt

To examine whether there are genetic differences between cytomegalovirus (CMV)-seronegative and CMV-seropositive adults, the polymorphisms of cytokine genes were analysed in a cohort of 400 adult blood donors. The genes and polymorphic sites studied were the tumour necrosis factor-alpha (TNF-alpha) gene (base exchange polymorphism at position -308; alleles TNF1 and TNF2) and the interleukin-1 receptor antagonist...

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