Article
IL-10 and TNF-alpha polymorphisms and the recovery from HCV infection.
Human immunology - 1 Jul 2003
Lio Domenico, Caruso Calogero, Di Stefano Rosa, Colonna Romano Giuseppina, Ferraro Donatella, Scola Letizia, Crivello Antonio, Licata Anna, Valenza L Mario, Candore Giuseppina, Craxì Antonio, Almasio Piero L
Abstract excerpt
Hepatitis C virus (HCV) infection becomes chronic in about 85% of infected individuals, whereas only 15% of infected people clear spontaneously the virus. It is conceivable that the host immunogenetic background influences the course of infection in term of recovery. Thus, in this study we have evaluated the effect of functionally relevant polymorphisms at tumor necrosis factor-alpha (TNF-alpha, i.e., 2 biallelic...
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