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Article

Increased helix and protein stability through the introduction of a new tertiary hydrogen bond.

Journal of molecular biology - 12 Mar 1999

Peterson R W, Nicholson E M, Thapar R, Klevit R E, Scholtz J M

Abstract excerpt

In an effort to quantify the importance of hydrogen bonding and alpha-helix formation to protein stability, a capping box motif was introduced into the small phosphocarrier protein HPr. Previous studies had confirmed that Ser46, at the N-cap position of the short helix-B in HPr, serves as an N-cap in solution. Thus, only a single-site mutation was required to produce a canonical S-X-X-E capping box: Lys49 at the...

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Identifiers

PMID: 10064718
DOI: 10.1006/jmbi.1999.2574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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