Article

Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function

2020-12-14

Abstract excerpt

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by brain-specific loss of UBE3A, an E3 ubiquitin protein ligase. A substantial number of possible ubiquitination targets of UBE3A have been identified, although evidence of being direct UBE3A substrates is often lacking. Here we identified the synaptic protein Rabphilin-3a (RPH3A), an effector of the RAB3A small GTPase involved in axonal vesicle...

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Literature Corpus work: e49f8330-cfed-5ef7-ac76-59522052fc11
DOI: 10.1101/2020.12.14.422704

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