Article

Validation and pre-analytical considerations for processing cerebrospinal fluid samples on a high-throughput proximity extension assay platform

2025-04-17

Abstract excerpt

<h4>Background</h4> Analysis of cerebrospinal fluid (CSF) facilitates the understanding of brain-specific molecular changes that may associate with disease progression. Proximity extension assays (PEA) have been deployed in several CSF studies, however the validation of the assay and impact of freeze-thaw cycles on the protein signal has not been documented. We sought to (1) validate the assay on the PEA platform...

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Literature Corpus work: feffcf63-d913-52bd-a203-db873ff77a05
DOI: 10.1101/2025.04.11.648439

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