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High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfection

2023-02-01

Abstract excerpt

In gene therapy, potential integration of therapeutic transgene into host cell genomes is a serious risk that can lead to insertional mutagenesis and tumorigenesis. Viral vectors are often used as the gene delivery vehicle, but they are prone to undergoing integration events. More recently, non-viral delivery of linear DNAs having modified geometry such as closed-end linear duplex DNA (CELiD) have shown promise as...

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Literature Corpus work
febaf2a4-b6c6-5047-ada7-9cb6eb2605fd
DOI
10.21203/rs.3.rs-2391398/v1
Open publication

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High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfectionDOI 10.21203/rs.3.rs-2391398/v1
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