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Article

Putative mechanisms of primary resistance to EGFR-targeted therapies: A retrospective study.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2024

Tu Xueliang, Lu Zhongyu, Hei Fengrong, Zhang Tong, Wang Xiaoxuan, Chen Dongsheng, Fan Fengjuan, Xu Jing, Zhang Xing, Guo Kefeng

Abstract excerpt

BACKGROUNDS: Advanced lung adenocarcinoma (LUAD) patient with EGFR mutations often experience resistance to first-line epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) therapy. Nonetheless, the mechanism and biomarkers of primary resistance remain unclear. Further exploration of independent prognostic factors will help clinicians identify patients who may not respond to EGFR-TKIs and select...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39490204
DOI: 10.1016/j.lungcan.2024.107998

Genes

EGFR
BTG2
C2
C3
EPAS1
PIK3C2G
STK11
CDKN2A
MUC16
MYC
RARA
RBM10
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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