Article

Cell type and cell signaling innovations underlying mammalian pregnancy

2024-05-02

Abstract excerpt

How fetal and maternal cell types have co-evolved to enable mammalian placentation poses a unique evolutionary puzzle. Here, we present a multi-species atlas integrating single-cell transcriptomes from six species bracketing therian mammal diversity. We find that invasive trophoblasts share a gene-expression signature across eutherians, and evidence that endocrine decidual cells evolved stepwise from an immunomodu...

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Literature Corpus work: fe3d70bc-eb5f-54a2-82e6-6b0373626166
DOI: 10.1101/2024.05.01.591945

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