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Article

Cell type and cell signalling innovations underlying mammalian pregnancy

1 Jul 2025

Abstract excerpt

How fetal and maternal cell types have co-evolved to enable mammalian placentation poses a unique evolutionary puzzle. Here we integrate and compare single-cell transcriptomes from six species bracketing therian mammal diversity: opossum (a marsupial), Malagasy common tenrec (an afrotherian), mouse and guinea pig (rodents), and macaque and human (primates). We identify a conserved transcriptomic signature of...

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PMID: 40596730
DOI: 10.1038/s41559-025-02748-x

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