Article

Can leptin-specific epigenetic modulation of preterm cord blood predispose obesity?

2024-12-16

Abstract excerpt

<h4>Objective</h4> This retrospective cohort investigated the role of leptin’s promoter methylation and microRNA targeting profile in developing adiposity and inflammation in neonates, using umbilical cord blood from preterm (n=67) and term (n=71) mothers. <h4>Methods</h4> Global DNA methylation and leptin promoter methylation were performed. ELISA determined leptin and IGF1 levels. Real-time PCR measured mRNA lev...

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Literature Corpus work: fd21b314-8fb4-5292-af0d-de7ab2af7bf9
DOI: 10.1101/2024.12.16.24319077

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