Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.

doi:10.1016/j.mce.2013.07.024

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Article

Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.

Molecular and cellular endocrinology - 5 Dec 2013

Lesseur Corina, Armstrong David A, Paquette Alison G, Koestler Devin C, Padbury James F, Marsit Carmen J

Abstract excerpt

Leptin a regulator of body weight is involved in reproductive and developmental functions. Leptin promoter DNA methylation (LEP) regulates gene expression in a tissue-specific manner and has been linked to adverse pregnancy outcomes. In non-pathologic human pregnancies, we assessed LEP methylation, genotyped the single nucleotide polymorphism (SNP) rs2167270 in placental (n=81), maternal and cord blood samples...

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PMID: 23911897
DOI: 10.1016/j.mce.2013.07.024
PMCID: PMC3795868

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