Article

Periodontopathogens interfere with the human renin-angiotensin system through surface-attached proteases

2024-06-21

Abstract excerpt

The renin-angiotensin system (RAS) executes its functions through biologically active peptides, angiotensins (Ang). Angiotensinogen-derived precursor, Ang I is cleaved by angiotensin-converting enzyme (ACE) into proinflammatory Ang II, which increases blood pressure. In the alternate pathway performed by neprilysin and ACE II, Ang 1-7 is produced from Ang I with activities opposite to Ang II. Here, we show that P...

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Literature Corpus work: fce68efc-c2e6-5db1-85fe-98eaee026b39
DOI: 10.1101/2024.06.20.599981

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