Article

Enforced dimerization of CD45 by the adenovirus E3/49K protein inhibits T cell receptor signaling

2023-02-23

Abstract excerpt

Human adenoviruses (HAdVs) are widespread pathogens that generally cause mild infections in immunocompetent individuals, but severe or even fatal diseases in immunocompromised patients. In order to counteract the host immune defenses HAdVs encode various immunomodulatory proteins in the early transcription unit 3 (E3). The E3/49K protein is a highly glycosylated type I transmembrane protein uniquely expressed by s...

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Literature Corpus work: fca9c195-6745-508a-a2c0-32c7ed33639b
DOI: 10.1101/2023.02.23.529489

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