Article

In Vivo Safety Evaluation of Silver Nanoparticle Encapsulated CRISPR/Cas9: Implications for HIV Gene Therapy

2026-04-07

Abstract excerpt

<title>Abstract</title> <p>Human immunodeficiency virus (HIV) persists in long-lived latent reservoirs that are not eliminated by antiretroviral therapy (ART), highlighting the need for curative strategies such as CRISPR/Cas9-mediated gene editing delivered through safe non-viral vectors. This study evaluated the short-term in vivo safety, physiological tolerance, hepatic effects, inflammatory responses, and apop...

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Literature Corpus work: fc643e02-73d0-5f70-9427-d2e0d7d25b32
DOI: 10.21203/rs.3.rs-9069279/v1

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