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The Clearance of Human Cytomegalovirus Using CRISPR/Cas9 RNA Lipid Nanoparticles

2025-12-17

Abstract excerpt

Human cytomegalovirus (HCMV), a DNA virus, poses significant health risks to immunocompromised and immunosuppressed individuals and newborns. Clinical antiviral drugs like ganciclovir inhibit viral replication but have toxicities, are ineffective against drug-resistant strains, and cannot destroy HCMV DNA. CRISPR/Cas9 can cleave DNA, but has not been used therapeutically to target and degrade HCMV DNA in cells pos...

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Literature Corpus work
e7f2f911-5383-5e85-84bc-c5ea2e24aa5f
DOI
10.64898/2025.12.17.694960
Open publication

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