Article

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC

2020-07-02

Abstract excerpt

<h4>Purpose</h4> The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target, therefore identifying druggable synthetic lethal interactions in MYC-active PDAC may lead to novel precise therapies. <h4>Methods</h4> Cluster analysis using direct MYC target genes was used to identify PDAC with active MYC. We...

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Literature Corpus work: fc53b8dc-633e-5061-a066-de98c4ab3388
DOI: 10.1101/2020.07.01.182162

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