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Multidimensional analyses identify genes of high priority for pancreatic cancer research

7 Jan 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a drug-resistant and lethal cancer. Identification of the genes that consistently show altered expression across patient cohorts can expose effective therapeutic targets and strategies. To identify such genes, we separately analyzed 5 human PDAC microarray datasets. We defined genes as "consistent" if upregulated or downregulated in 4 or more datasets (adjusted P <...

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PMID: 39774001
DOI: 10.1172/jci.insight.174264

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